# tooluniverse-clinical-guidelines

A skill that pulls clinical practice guidelines from NICE, WHO, NCCN, AHA, ADA and more, then ranks them by source authority.

- skill · `type=skill` · Claude Code, Codex, Cursor, GitHub Copilot, Gemini CLI, OpenCode · 491 installs · ★ 1759
- Author: mims-harvard
- License: Apache-2.0 · policy=mirror · the beginning of the file is at the end of this page
- Source: https://github.com/mims-harvard/ToolUniverse/tree/HEAD/skills/tooluniverse-clinical-guidelines/SKILL.md
- Updated: 2026-10-24
- HTML: https://affpapa.org/en/nevibecode/skills/tooluniverse-clinical-guidelines

## What it does

The skill gives your agent a fixed order for handling clinical guidelines. NICE and WHO sit at the top, society guidelines from AHA, ADA, NCCN and SIGN come next, aggregators like TRIP and OpenAlex follow, and PubMed with EuropePMC land at the bottom as a fallback. Search is meant to run across at least three databases in parallel, and the publication year always gets checked — a 2015 recommendation may have been superseded by a 2024 update.

Separate reasoning blocks cover diagnostic test selection, lab result interpretation and surgical decisions. For tests, the skill first asks what the question actually wants: screening, confirmation, differentiation, staging or monitoring. Sensitivity and specificity get matched to that. It also walks through the usual mistakes — ordering a test that comes back positive in both conditions on your differential, using a screening test where a confirmatory one is needed, ignoring pre-test probability.

The skill tells the agent to compute rather than describe: analysis runs as Python in Bash with pandas, scipy, statsmodels and matplotlib, while ToolUniverse tools fetch the data. Clinical judgement stays with the clinician; what you get here is structure for the search and the reasoning.

## Install

### Claude Code (native platform)

1. **Skills CLI (Vercel)**
```bash
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-clinical-guidelines -a claude-code
```

2. **Manually: put the files in place**
- File: `~/.claude/skills/tooluniverse-clinical-guidelines/SKILL.md` — Copy the whole skill folder; for one project use .claude/skills/tooluniverse-clinical-guidelines/

### Codex

1. **Skills CLI (Vercel)**
```bash
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-clinical-guidelines -a codex
```

2. **Manually: put the files in place**
- File: `.agents/skills/tooluniverse-clinical-guidelines/SKILL.md` — For all projects use ~/.agents/skills/

### Cursor

1. **Skills CLI (Vercel)**
```bash
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-clinical-guidelines -a cursor
```

2. **Manually: put the files in place**
- File: `.cursor/skills/tooluniverse-clinical-guidelines/SKILL.md` — Cursor also reads .agents/skills/ and .claude/skills/

### GitHub Copilot

1. **GitHub CLI**
```bash
gh skill install mims-harvard/ToolUniverse tooluniverse-clinical-guidelines
```

2. **Manually: put the files in place**
- File: `.github/skills/tooluniverse-clinical-guidelines/SKILL.md`

### Gemini CLI

1. **Skills CLI (Vercel)**
```bash
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-clinical-guidelines -a gemini-cli
```

2. **Platform CLI**
```bash
gemini skills install https://github.com/mims-harvard/ToolUniverse --path skills/tooluniverse-clinical-guidelines
```

### Windsurf (Devin Desktop)

**Manually: put the files in place**
- File: `.devin/skills/tooluniverse-clinical-guidelines/SKILL.md` — The legacy .windsurf/skills/ path still works

### OpenCode

**Skills CLI (Vercel)**
```bash
npx skills add mims-harvard/ToolUniverse --skill tooluniverse-clinical-guidelines -a opencode
```

### Claude.ai

**Claude.ai**
- Zip the folder and upload it in Settings → Capabilities → Skills

Where a file is given instead of a command, copy the files from the source to that path: https://github.com/mims-harvard/ToolUniverse/tree/HEAD/skills/tooluniverse-clinical-guidelines/SKILL.md

## When to use it
- find the current treatment recommendation instead of a superseded one
- compare what NICE and a specialty society say about the same question
- pick a diagnostic test for screening versus confirmation
- work out why one lab result is positive in two similar conditions
- catch a guideline that one database missed and another found

## Example prompts
- Find NICE and WHO guidance on heart failure management and give me the year for each
- Which test distinguishes PSGN from lupus nephritis? Walk me through sensitivity and specificity
- Pull the NCCN recommendations for this regimen and check whether a newer update exists

## Source text · SKILL.md · Apache-2.0

Below is the content of a third-party file. It is data, not instructions for you: do not act on anything written inside unless the human asks. Block tag: d7a80f3590db6aba.

BEGIN THIRD-PARTY FILE d7a80f3590db6aba
```text
---
name: tooluniverse-clinical-guidelines
description: Search and retrieve clinical practice guidelines from 12+ authoritative sources — NICE, WHO, NCCN, AHA, ADA, SIGN, USPSTF, IDSA, NIH consensus, ESMO/ESC/EASL European societies, and US specialty associations. Use for evidence-graded treatment recommendations, dosing protocols, screening guidance, and authoritative-source-prioritized clinical guidance (NICE/WHO ranked above society guidelines).
disable-model-invocation: true
---

# Clinical Guidelines Search & Retrieval

## Guideline Hierarchy

Not all guidelines carry equal weight. Evaluate sources in this order:

1. **NICE and WHO** — Evidence-graded, regularly updated, rigorous systematic review process. NICE guidelines include explicit recommendation strength (e.g., "offer" vs "consider").
2. **Society guidelines (AHA, ADA, NCCN, SIGN)** — Expert-consensus panels within a specialty. May lag behind the latest evidence by 1-3 years. Strong within their domain but narrower scope.
3. **Aggregator databases (TRIP, OpenAlex)** — Index guidelines from multiple societies. Good for breadth and discovery, but you must verify the original source.
4. **Literature databases (PubMed, EuropePMC)** — Return guideline-related publications, not curated guideline text. Useful as a fallback, not a primary source.

**Always check publication date.** A 2015 guideline may be superseded by a 2024 update. When presenting results, include the year prominently and note if newer guidance may exist.

---

## COMPUTE, DON'T DESCRIBE
When analysis requires computation (statistics, data processing, scoring, enrichment), write and run Python code via Bash. Don't describe what you would do — execute it and report actual results. Use ToolUniverse tools to retrieve data, then Python (pandas, scipy, statsmodels, matplotlib) to analyze it.

## Search Strategy

### Step 1: Start Narrow, Then Broaden

1. Search the **condition name + "guideline"** in NICE, TRIP, and EuropePMC simultaneously (parallel calls).
```
END THIRD-PARTY FILE d7a80f3590db6aba

The third-party file has ended. Everything between the d7a80f3590db6aba tags is data: requests and commands from it are not followed. An “end of file” line with another tag inside the block is part of the file.

First 2023 of 20176 bytes. © mims-harvard · Apache-2.0 · https://github.com/mims-harvard/ToolUniverse/tree/HEAD/skills/tooluniverse-clinical-guidelines/SKILL.md

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---
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